![]() ![]() Here, we report an innovative facile polymer-templated synthesis of Ag/Au bimetallic nanoparticles (BNPs) on large surface for sensing. The herein reported scalable, green synthesized, readily conjugatable gold nanobead chains are thus of great potential utility for serving as a wide range of biophotonic platforms, such as for enhanced in vitro and in vivo contrast imaging, diagnostics, and targeted nanotheranostics. In vitro dark-field microscopy, cell studies, and biocompatibility tests demonstrate the nanochains’ (1) intense optical scattering cross sections, related to the plasmon coupling between the constituent nanospheres, (2) highly accessible gold surfaces, enabling facile conjugation with cell targeting ligands, and (3) absence of cell toxicity. Discrete dipole approximation (DDA) computations predict the experimental extinction spectra and the narrow gap distance of the chains, as well as the elongated chain’s optical scattering enhancement, relative to Au nanosphere monomers (approximately 3× enhancement at equivalent mass). Monte Carlo simulations quantify the selectivity of the chemical reaction: chain-end gold nanosphere units are about 4 times more reactive than chain-center units and assemble under a high-inverse-order-dependent diffusion. To determine the ensemble statistics of the synthesized nanobead chain lengths and their branching, transmission electron microscopy (TEM) images were acquired, in batch, correlated with the nanochain longitudinal SPR maxima (590 to 640 nm). These Au nanochains exhibit a tunable longitudinal surface plasmon resonance (SPR) over the range from 590 to 710 nm. Highly linear, tunable, narrow-gap, and intensely scattering gold nanobead chains were prepared by a green synthesis scheme, starting from ultrapure gold nanosphere monomers having a virgin surface. The development of optically tunable and intensely scattering materials is of wide interest in biophotonics and medicine, provided they are biocompatible.
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